discoid lupus erythematosus

Bitte logge Dich ein, um diesen Artikel zu bearbeiten. Correlation of clinical features with laboratory findings in lupus erythematosus. [5] If a patient does not have any signs of systemic lupus erythematosus, such as generalized hair loss, ulcers in the mouth or nose, Raynaud's phenomenon, arthritis, or fever at the time that they develop discoid lupus, they will most likely only have discoid lupus and will never develop systemic lupus erythematosus. Der diskoide Lupus erythematodes ist eine Autoimmundermatose, deren genauer Pathomechanismus bislang (2018) noch nicht geklärt ist. [5] Evidence does not clearly demonstrate a genetic component to DLE; however, genetics may predispose certain people to disease. [3], In general, patients with discoid lupus who have only skin disease and no systemic symptoms have a genetically distinct disease from patients with SLE. [5] The doctor will order tests to check for anti-nuclear antibodies in the patient's serum, low white blood cell levels, and protein and/or blood in the urine. [5] Typical biopsy findings include deposits of IgG and IgM antibodies at the dermoepidermal junction on direct immunofluorescence. Diese Seite wurde zuletzt am 14. In non-responders or after secondary resistance or contraindications, there are a number of alternative therapeutics which are less effective and more toxic. Hypertrophic lupus erythematosus (HLE) may be more common as a variant of discoid lupus erythematosus (DLE) than is reported in the literature. Der diskoide Lupus erythematodes ist eine Autoimmundermatose, deren genauer Pathomechanismus bislang (2018) noch nicht geklärt ist. [3] Patients with generalized discoid lupus often have abnormal lab tests, such as an elevated ESR or a low white blood cell count. cutis = Haut) (CLE), auch Lupus erythematodes cutaneus oder Hautlupus, ist meistens nur die Haut betroffen. Die Herde sind randbetont. List of cutaneous conditions associated with increased risk of nonmelanoma skin cancer, "Cutaneous Lupus Erythematosus | American Skin Association", "Ocular Complications in Cutaneous Lupus Erythematosus: A Systematic Review with a Meta-Analysis of Reported Cases", "Journal of the American Academy of Dermatology", "A Systematic Review of the Outcome of Hair Transplantation in Primary Scarring Alopecia", "At Lunch With: Seal; From a Crucible Of Early Pain Comes the Gold Of Stardom", Opinion:To understand Michael Jackson and his skin, you have to go beyond race, "Cutaneous lupus erythematosus in dogs: a comprehensive review", Seborrheic keratosis with squamous atypia, Palisaded neutrophilic and granulomatous dermatitis, Lupus erythematosus–lichen planus overlap syndrome, Morphea–lichen sclerosus et atrophicus overlap, https://en.wikipedia.org/w/index.php?title=Discoid_lupus_erythematosus&oldid=1000946900, Creative Commons Attribution-ShareAlike License, Discoid lupus erythematosus lesion on the face of musician, This page was last edited on 17 January 2021, at 14:08. [3][5] In addition to lesions in the typical above-the-neck locations, patients with generalized discoid lupus often have lesions on the thorax and the arms. Eine erhöhte Lichtempfindlichkeit ist bei Lupus erythematodes häufig, und so zeigen sich die Hautveränderungen auch meist auf lichtexponierten Stellen, typischerweise als „Schmetterlingserythem“ im Gesicht. Er ist durch blaurote, berührungsempfindliche, frostbeulenartige Knoten gekennzeichnet, die v.a. Auf unbefallener Haut ist der Test negativ. Discoid lupus erythematosus (DLE) is responsible for 50-85% of cases of CLE and occurs 2-3 times more frequently in women than in men. [3], Sun exposure triggers lesions in people with discoid lupus erythematous (DLE). [4] On darker skin, the lesions often lose skin pigmentation in the center and develop increased, dark skin pigmentation around the rim. [5] Patients are first treated with sunscreen and topical steroids. Englisch: discoid lupus erythematosus. [3][5] This finding is 90% sensitive; however, false positives can occur with biopsies of facial lesions. Es handelt sich um die häufigste Form des kutanen Lupus erythematodes. Der diskoide Lupus erythematodes kommt weltweit vor. 2020 Jan. 45 (1):89 … [3] These patients are often bald, with abnormal skin pigment on their scalp, and have severe scarring of the face and arms. Boys and girls are equally affected, and these patients later develop SLE more often. Description The disease called discoid lupus erythematosus only affects the skin, although similar discoid skin lesions can occur in the serious disease called systemic lupus erythematosus (SLE). DLE usually presents in people aged between 20 and 40 years of age. discoid lupus erythematosus causes. Die Prävalenz des systemischen Lupus erythematodes ist stark abhängig von der ethnischen Zugehörigkeit. Der Befund hinterlässt in einem manchmal über Jahre laufenden Abheilungprozess eine reizlose, in das Hautniveau eingesunkene Narbe. [3] They can have a smooth surface or have visible, dilated hair follicles on the surface. 1975 Nov. 111(11):1448-52. . [3] They also often have auto-antibodies, such as ANA or anti-ssDNA antibody. Dust Mites: Minimizing Exposure in Dogs and Cats. [3], When discoid lupus is on the scalp, it starts as a red flat or raised area of skin that then loses hair and develops extensive scarring. Dry Eye (Keratoconjunctivitis Sicca) in Dogs and Cats . In Europa liegt sie zwischen 25 und 40 Fällen auf 100.000 Einwohner, in Asien beträgt sie rund 50 Fälle pro 100.000 Einwohner. How to say discoid lupus erythematosus in English? Discoid lupus erythematosus (DLE) is a form of lupus that mainly affects your skin. an Zehen und Fingern auftreten. [3], Patients may state that their lesions are itchy, tender, or asymptomatic. Im Stratum basale kommt es zu einer Degeneration der Stammzellen mit zahlreichen Einzelzellnekrosen, die sich als eosinophile Zellrest… [4], Of note, patients with systemic lupus erythematous develop discoid lupus lesions with some frequency. [4], Treatment for discoid lupus erythematosus includes smoking cessation and a sunscreen that protects against both UVA and UVB light as well as very strong topical steroids or steroids injected into the lesions. [3], The musician Seal has this skin condition. Lupus erythematosus is a collection of autoimmune diseases in which the human immune system becomes hyperactive and attacks healthy tissues. Hyperpigmentierungen und Teleangiektasien kommen ebenfalls vor. Synonyme: chronisch diskoider Lupus erythematodes, CDLE, Lupus erythematodes chronicus discoides [3][5] These lesions then develop increasing amounts of white, adherent scale. Neben Umweltfaktoren (z.B. [4] However, patients who present initially with discoid lupus infrequently develop systemic lupus. Hautreizungen (z.B. Im oberen Korium sieht man als Zeichen der Immunreaktion ein perivasales Infiltrat aus Lymphozyten sowie einen Abbau der Kollagenfasern und elastischen Fasern. It presents with red, inflamed, coin-shaped patches of skin with a scaling and crusty appearance, most often on the scalp, cheeks, and ears. Samotij D, Szczech J, Kushner CJ, Mowla MR, Danczak-Pazdrowska A, Antiga E, et al. Beim kutanen Lupus erythematodes (lat. Die Erkrankung äußert sich durch rötliche, scheibenförmige Hautareale, die häufig, aber nicht immer, mit festhaftenden Schuppen und Krusten belegt sind. Der diskoide Lupus erythematodes, kurz DLE, ist ein Subtyp des kutanen Lupus erythematodes (CLE). [11], Singer Michael Jackson was reportedly diagnosed with discoid lupus in 1984; the condition might have damaged his nasal cartilage and led to some of his cosmetic surgery. Acute cutaneous lupus erythematosus (ACLE) most commonly presents as symmetric erythema overlying the malar cheeks and nasal bridge with sparing of the nasolabial folds (butterfly rash).

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